Genexpress Team and Systemoscope Consortium Functional Genomics and Systems Biology for Health CNRS - Institute of Biological Sciences Principal Investigator: Dr Charles AUFFRAY 7 rue Guy Môquet - bat.G - 94801 Villejuif Cedex - France Tél : +33 (0)1 49 58 34 97/98 - Fax : +33 (0)1 49 58 35 09 email: auffray@vjf.cnrs.fr

Genexpress Team

Functional Genomics - ArraysIMAGE




Computational Genomics - Genexpress Index




Integrated Human Gene Database - H-Invitational

Publications (pdf format)




- Imanishi, T., & al. (2004) Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol. 2, 856-875.
- Tanino, M., & al. (2005) The Human ANatomic Gene Expresssion Library (HANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms. Nucl. Acids Res. 33, D567-572.
- Yamasaki, C., & al. (2008) H-Invitational Database (H-InvDB) Comprehensive annotation resource of the human genes and transcripts. Nucl. Acids. Res. 36, D793-799.

Systemoscope Consortium

International Consortium

	Charles AUFFRAY (CV) CNRS - Institute of Biological Sciences - Villejuif, France
	Lee HOOD Institute for Systems Biology - Seattle, USA
	Zhu CHEN Shanghai Center for Systems Biomedicine, China

Publications 2003-2009 (pdf format) - Auffray, C., Imbeaud, S., Roux-Rouquié, M. and Hood, L. (2003) Self-organized living systems: conjunction of a stable organization with chaotic fluctuations in biological space time. Phil. Trans. R. Soc. Math. Phys. Eng. Sci. 361, 1125-1139. - Auffray, C., Chen, Z., Hood, L., Soares, B., and Sugano, S. (2003) Foreword: from the TRANSCRIPTOME conferences to the SYSTEMOSCOPE International Consortium (Editorial). C. R. Biologies 326, 867-875. - Auffray, C., Imbeaud, S., Roux-Rouquié, M. and Hood, L. (2003) From functional genomics to systems biology: concepts and practices (Review). C. R. Biologies 326, 879-882. - Auffray, C., Chen, Z. and Hood, L. (2009) Systems medicine: the future of medical genomics and heathcare.Genome Med. 1, 2. - Auffray, C. (2009) Sharing knowledge: a new frontier for public-private partnerships in medicine. Genome Med. 1, 29. - Tegner et al. (2009) Computational disease modeling - fact or fiction? BMC Syst. Biol. 3, 56 - Clermont et al. (2009) Bridging the gap between systems biology and medicine. Genome Med. 1, 88.




French Consortium

	Charles AUFFRAY CNRS - Institute of Biological Sciences - Villejuif.
	Dominique CHARRON INSERM U940 and Denis Diderot University - Paris VII.
	Jean-Pierre FRANCOISE UMR 7598 - Pierre & Marie Curie University - Paris VI and CNRS.
	Giuseppe LONGO UMR 8548 - Ecole Normale Supérieure and CNRS - Paris.
	Jacques MALLET UMR 7225 - CNRS and Pierre & Marie Curie University- Paris VI.
	Laurent NOTTALE UMR 8102 - Paris-Meudon Observatory, CNRS and Denis Diderot University - Paris VII.
	Christophe PISON INSERM U884 and Albert Michallon Hospital - Joseph Fourier University - Grenoble.




Bibliography

Projects

Cancer System Biology

Publications (pdf format)




- Zheng et al. (2005) Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 102, 7653-7658.
- Graudens et al. (2006) Deciphering cellular states of innate tumor drug responses. Genome Biol. 7, R19.
- Aebersold et al. (2009) Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008). Mol. Onc. 3, 9-17.
- Debily et al. (2009) A Functional and Regulatory Network Associated with PIP Expression in Human Breast Cancer. PLoS ONE 4, e4696.





Systems Biology of Respiratory Diseases

U-BioPred - Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome






Scale Relative Biology

	Charles AUFFRAY (CV) CNRS - Institute of Biological Sciences - Villejuif, France
	Denis NOBLE (CV) Department of Physiology, Anatomy & Genetics - Oxford University, UK
	Laurent NOTTALE

Publications (pdf format) - Auffray, C. and Nottale, L. (2008) Scale relativity and integrative systems biology: 1. Founding principles and scale laws. Prog. Biophys. Mol. Biol. 97, 79-114. - Nottale, L. and Auffray, C. (2008) Scale relativity and integrative systems biology: 2. Macroscopic quantumtype mechanics. Prog. Biophys. Mol. Biol. 97, 115-157. - Noble D. (2008) Claude Bernard, the first systems biologist, and the future of physiology. Exp Physiol., 93, 16-26 - Auffray, C. and Noble D. (2009) Origins of Systems Biology in William Harvey's Masterpiece on the Movement of the Heart and the Blood in Animal. Int. J. Mol. Sci. 10, 1658-1669.

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Last update: September 4th 2009

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