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The CRRET (UPEC) leader of the project “ArrestAD” for the European program H2020 Novel Ideas for Radically New Technologies
The scientific leader and coordinator of the “ArrestAD” project is the Professor Dulcé Papy-Garcia, who heads the CRRET laboratory, at the Faculty of Sciences and Technology of UPEC. This team recently demonstrates the central role of a particular type of sugar chain, heparan sulfate, as a catalyst of biochemical and cellular processes leading to the development of Alzheimer’s disease.
The program brings together an international consortium with academic and clinical research teams of high levels, which include in addition to laboratory CRRET, the institute of Memory and Alzheimer Disease from the Assistance Publique-Hôpitaux de Paris, scientific teams from different European universities: Universidad Autónoma de Barcelona (Spain), Universidad de Salamanca (Spain), Radboud University Medical Centre Nijmegen (Netherlands), the Necki Institute of Experimental Biology of Warsaw (Poland), the University of Liverpool (England) and a French industrial partner Paris-based, the SME ScreenCell.
At the origin of this new strategy, starting from pathophysiological mechanisms to prognostic and therapeutic of Alzheimer’s disease, the research team in glycobiologie from the laboratory CRRET is centrally involved in the different axes of the program thanks to the expertise of its researchers in chemistry, heparan sulfate biology, biochemistry, cellular biology and physiology.
The “FET-OPEN Novel Ideas for Radically New Technologies” is extremely selective, with just 4% of the proposals funded (22 projects selected on 544 evaluated and only 1 in France in the field of Life Sciences). It supports research projects based on new ideas emerging from recent blue skies research, oriented towards the future development of radically different technologies that can change society over the coming decades.
"This program is financed by the program R&D H2020 FET-OPEN RIA of European Commission by subvention contract n°737390".
Contact : D. Papy-Garcia (papy@u-pec.fr)
Key paper, UPEC, Sepulveda-Diaz et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology
Assistance Publique des Hôpitaux de Paris (APHP)
Necki Institute of Experimental biology (NECKI)
Universitat Autònoma de Barcelona (UAB)
Radboud University Medical Centre (RUMC)
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