Gly-CRRET Laboratory :

Growth, Repairing and Regeneration of Tissues

Partenaires

CNRS
Logo tutelle Logo tutelle
Logo tutelle Logo tutelle

Logo tutelle

Search

On the whole CNRS Web


Home page > News > The CRRET (UPEC) leader of the project “ArrestAD” for the European program H2020 Novel Ideas for Radically New Technologies

The CRRET (UPEC) leader of the project “ArrestAD” for the European program H2020 Novel Ideas for Radically New Technologies

03/03/2017 - The European “ArrestAD” project, coordinate by the CRRET laboratory and targeting Alzheimer disease, has been selected with the highest evaluation score under the European Program for Research and Innovation “H2020 FET-OPEN Novel Ideas for Radically New Technologies”. This project proposes a completely new vision for research on Alzheimer’s disease and tests a new concept for its early diagnosis and treatment.

The scientific leader and coordinator of the “ArrestAD” project is the Professor Dulcé Papy-Garcia, who heads the CRRET laboratory, at the Faculty of Sciences and Technology of UPEC. This team recently demonstrates the central role of a particular type of sugar chain, heparan sulfate, as a catalyst of biochemical and cellular processes leading to the development of Alzheimer’s disease.

The program brings together an international consortium with academic and clinical research teams of high levels, which include in addition to laboratory CRRET, the institute of Memory and Alzheimer Disease from the Assistance Publique-Hôpitaux de Paris, scientific teams from different European universities: Universidad Autónoma de Barcelona (Spain), Universidad de Salamanca (Spain), Radboud University Medical Centre Nijmegen (Netherlands), the Necki Institute of Experimental Biology of Warsaw (Poland), the University of Liverpool (England) and a French industrial partner Paris-based, the SME ScreenCell.

At the origin of this new strategy, starting from pathophysiological mechanisms to prognostic and therapeutic of Alzheimer’s disease, the research team in glycobiologie from the laboratory CRRET is centrally involved in the different axes of the program thanks to the expertise of its researchers in chemistry, heparan sulfate biology, biochemistry, cellular biology and physiology.

The “FET-OPEN Novel Ideas for Radically New Technologies” is extremely selective, with just 4% of the proposals funded (22 projects selected on 544 evaluated and only 1 in France in the field of Life Sciences). It supports research projects based on new ideas emerging from recent blue skies research, oriented towards the future development of radically different technologies that can change society over the coming decades.

"This program is financed by the program R&D H2020 FET-OPEN RIA of European Commission by subvention contract n°737390".

Contact : D. Papy-Garcia (papy@u-pec.fr)



- Key paper, UPEC, Sepulveda-Diaz et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology spacer

upec-1
ce-2

sceencells-1
- ScreenCell spacer

ap-2
- Assistance Publique des Hôpitaux de Paris (APHP) spacer

nenky-1
- Necki Institute of Experimental biology (NECKI) spacer

barcelone-2
- Universitat Autònoma de Barcelona (UAB) spacer

salamanc-cic-2
- University of Salamanca spacer

radboud-1
- Radboud University Medical Centre (RUMC) spacer

liverpool-1
- University of Liverpool spacer


In the headlines

Vignette une

Weibel-Palade bodies orchestrate pericytes during angiogenesis

08/08/2019 - This study performed at CRRET laboratory and published in the journal ATVB demonstrated that WPB Weibel-Palade bodies (WPBs) exocytosis and Ang-2 secretion are regulated during angiogenesis to limit pericyte coverage of remodeling vessels by disrupting Ang-1/Tie2 autocrine (...)

Read more

News

Vignette une

Team of Pr Patricia Albanese was awarded at the 31 meeting of the French Society of Rheumatology.

12/02/2019 - Professor Patricia Albanese’s Team had received a Fundamental Research Award from the “Fondation Arthrose”, on December 10th 2018, at the 31st Congress of the French Society of Rheumatology. Founded by Tilman Laboratory SA, this prize is awarded with the aim to promote fundamental (...)

Read more

Vignette une

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau.

23/01/2019 - Glycosaminoglycans (GAGs), including heparan sulfates and chondroitin sulfates, are major components of the extracellular matrix. Brain-derived neurotrophic factor (BDNF) neuritogenic activity on human neuroblastoma SH-SY5Y cells culture. Neurite length was higher in presence of (...)

Read more

Vignette une

Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters in vitro synaptic structural matching and exaggerates protein synthesis .

05/09/2017 - En2 is a gene of susceptibility to autism and people with autism display an overexpression of En2 protein, but the effects of this overexpression are not known. Automatic detection and analysis of synaptic junctions areas. Details in sup. data at this link In a study published (...)

Read more

Vignette une

The CRRET (UPEC) leader of the project “ArrestAD” for the European program H2020 Novel Ideas for Radically New Technologies

03/03/2017 - The European “ArrestAD” project, coordinate by the CRRET laboratory and targeting Alzheimer disease, has been selected with the highest evaluation score under the European Program for Research and Innovation “H2020 FET-OPEN Novel Ideas for Radically New Technologies”. This project (...)

Read more

Vignette une

Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer

31/05/2016 - The study participates to the molecular understanding of the mechanisms involved in prostate cancer progression and to the research of new treatment options for its advanced forms. Despite the advent of several new treatment options over the past years, advanced prostate carcinoma (...)

Read more

Other news: 0 | 5 | 10 | 15 | 20 | 25 | 30 | 35